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Updated: May 1, 2026

Retroviral Transduction of Helper T Cells as a Genetic Approach to Study Mechanisms Controlling their Differentiation and Function
Published on: November 4, 2016
Transcriptional control of regulatory T-cell differentiation
Joris van der Veeken1, Aaron Arvey1, Alexander Rudensky2
1Howard Hughes Medical Institute, New York, New York 10065.
Abstract:
Regulatory T (Treg) cells are essential for maintaining peripheral tolerance and for limiting excessive inflammatory responses under various conditions. The lineage-specific transcription factor Foxp3 has a critical role in Treg-cell biology. Foxp3 forms large protein complexes and cooperates with environmentally induced transcription factors to shape the Treg-cell transcriptional program. Here, we discuss mechanisms of gene regulation that underlie Treg-cell differentiation and function with an emphasis on studies from our laboratory.
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