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Updated: May 1, 2026

Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model
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Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model

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Mast cell sarcoma: clinical management.

Catherine R Weiler1, Joseph Butterfield1

  • 1Program of Excellence in Mast Cell and Eosinophil Disorders, Division of Allergic Disease, Department of Internal Medicine, W-15 Mayo Building, 200 First Street Southwest, Rochester, MN 55905, USA.

Immunology and Allergy Clinics of North America
|April 22, 2014
PubMed
Summary
This summary is machine-generated.

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Mast cell sarcoma is a rare disorder of abnormal mast cells, more common in canines than humans. This condition has a poor prognosis in humans, with no standard treatment available.

Area of Science:

  • Veterinary Pathology
  • Human Pathology
  • Oncology

Background:

  • Mast cell sarcoma is a neoplastic proliferation of abnormal mast cells.
  • Diagnosis relies on morphology, special stains, and c-kit mutation analysis.
  • This condition is more prevalent in canines than humans.

Purpose of the Study:

  • To summarize the key aspects of mast cell sarcoma.
  • To highlight its rarity and variable presentation in humans.
  • To discuss the lack of standard therapeutic options.

Main Methods:

  • Review of existing literature on mast cell sarcoma.
  • Analysis of diagnostic criteria including morphology and c-kit mutation.
  • Examination of clinical presentation and associations.
Keywords:
Clinical presentation of mast cell sarcomaMast cell sarcomaMastocytosisPrognosis of mast cell sarcomaTreatment of mast cell sarcoma

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Last Updated: May 1, 2026

Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model
13:41

Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model

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Main Results:

  • Mast cell sarcoma is characterized by abnormal mast cells.
  • It affects canines more frequently than humans.
  • Human cases exhibit variable clinical presentations and poor prognosis.

Conclusions:

  • Mast cell sarcoma is a rare and aggressive malignancy.
  • There is no established standard therapy for human cases.
  • The condition can be associated with systemic mastocytosis or urticaria pigmentosa.