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Cell adhesion molecules in neural development.

D Linnemann1, E Bock

  • 1Research Center for Medical Biotechnology, University of Copenhagen, Denmark.

Developmental Neuroscience
|January 1, 1989
PubMed
Summary
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Cell adhesion molecules are crucial for brain development. This review details the structure, localization, and function of key molecules like NCAM and N-cadherin involved in brain morphogenesis.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Cell Biology

Background:

  • Adhesive mechanisms play vital roles in developmental morphogenesis.
  • Several cell-cell and cell-substrate adhesion molecules have been identified in recent years.
  • These molecules are critical for understanding tissue formation and development.

Purpose of the Study:

  • To review the current data on specific adhesion molecules in the brain.
  • To discuss their structure, localization, developmental regulation, and function.
  • To highlight their importance in brain morphogenesis.

Main Methods:

  • Literature review of characterized adhesion molecules.
  • Analysis of data on structure and localization.
  • Examination of developmental regulation and functional studies.

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Main Results:

  • Four key cell-cell adhesion molecules in the brain: NCAM, L1, myelin-associated glycoprotein, and N-cadherin.
  • A cell-substrate adhesion molecule, cytotactin, and its proteoglycan ligand have been described.
  • Data on the structure, localization, developmental regulation, and function of these molecules are presented.

Conclusions:

  • Cell adhesion molecules are integral to brain development and morphogenesis.
  • Understanding these molecules provides insight into neural development.
  • Further research into their roles can uncover new therapeutic targets.