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Adaptogenic effects of dihydroquercetin-chitosan composition during modeling of acute hypoxia
E I Murach1, I A Baranov, E I Erlykina
1Nizhny Novgorod State Medical Academy, Ministry of Health of the Russian Federation, Nizhny Novgorod, Russia.
Bulletin of Experimental Biology and Medicine
|April 29, 2014
Abstract:
The course of preventive oral treatment with a dihydroquercetin-chitosan composition produced a strong antihypoxic effect under conditions of experimental hypobaric hypoxia (arbitrary altitude 12,000 m). The lactate/pyruvate ratio in composition-receiving rats was much lower than in hypoxic animals (by 83%), but higher than in intact specimens (by 29%). The composition of chitosan and dihydroquercetin also possessed a strong antioxidant activity.
