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Updated: Jul 25, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
[A stat-method of determining antibiotic concentration in biological fluids]
Abstract:
The rapid method for measuring antibiotic concentrations in biologic substrates, developed by the authors, is based on the suppression of Staphylococcus aureus 209 P test culture dehydrogenase activity. Comparison of the rapid method and the routine agar diffusion test has shown a high correlation of the results, the correlation coefficient r being 0.84-0.93 and its probability 99.9%. The new technique permits getting an answer in 4 hours, is simple, and saves nutrient media.
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