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Phosphorylated dendronized poly(amido amine)s as protein analogues for directing hydroxylapatite biomineralization
Jianyu Xin1, Tianchan Chen, Zaifu Lin
1College of Polymer Science and Engineering, Sichuan University, Chengdu, China. jianshu_li@scu.edu.cn.
Chemical Communications (Cambridge, England)
|May 13, 2014
Abstract:
Dendronized poly(amido amine)s (DPs) bearing tri-phosphate or bis-phosphonate peripheral groups are synthesized. These worm-like DPs can template the formation of BMSCs adhesive hydroxylapatite (HA) on the nano-scale, or self-assemble into mineral-collecting microfibers on the micro-scale, exhibiting similar functions of non-collagenous proteins (NCPs) in the natural biomineralization process of HA.
