Methods of identification of pseudogenes based on functionality: hybridization of 18S rRNA and mRNA during
1Department of Biostatistics, Boston University, School of Public Health, Boston, MA, USA, chuanhua.xing@gmail.com.
Methods in Molecular Biology (Clifton, N.J.)
|May 15, 2014
Abstract:
Protein-coding sequences are characterized by a period-3 free energy signal that arises from the interaction between the 3'-terminal nucleotides of the 18S rRNA and the mRNA. Such a signal is not present in noncoding sequences such as introns and intergenic regions and can be used for pseudogene identification.
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