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Cutaneous late phase responses--an allergic inflammatory response.
1Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia 19104.
Allergy Proceedings : the Official Journal of Regional and State Allergy Societies
|November 1, 1989
Summary
Late phase cutaneous responses result from activated inflammatory cells releasing mediators hours after mast cell activation. These cells contribute to allergic skin reactions, causing swelling and induration.
Area of Science:
- Immunology
- Dermatology
- Allergy Research
Background:
- Cutaneous late phase responses are linked to mast cell activation.
- These responses can be triggered by both immune and nonimmune mechanisms.
Purpose of the Study:
- To review laboratory studies on the mechanisms of late phase cutaneous responses.
- To highlight the role of activated inflammatory cells in these responses.
Main Methods:
- Review of laboratory studies focusing on mast cell activation and subsequent inflammatory cell migration.
- Analysis of mediator release from activated inflammatory cells in cutaneous tissues.
Main Results:
- Inflammatory cells migrating to the site of mast cell activation become activated.
- These activated cells release mediators that cause delayed edematous and indurated skin responses.
- These responses are termed late phase cutaneous responses.
Conclusions:
- Activated inflammatory cells play a crucial role in the pathogenesis of late phase cutaneous responses.
- Understanding this mechanism is key to managing allergic skin conditions.