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Efficient synthesis of fluorescent-PET probes based on [¹⁸F]BODIPY dye
Shuanglong Liu1, Dan Li, Zhe Zhang
1Molecular Imaging Center, Radiology Department, University of Southern California, 2250 Alcazar St CSC103, Los Angeles, CA, USA. ziboli@usc.edu.
Abstract:
We report the direct conversion of fluorescent probes to PET/fluorescent probes after efficient [(19)F]/[(18)F] exchange at the BODIPY motif. The radiolabeling of a NIR BODIPY dye was also established, which was conjugated with the RGD peptide for PET/fluorescence imaging of integrin expression in vivo.
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