Related Experiment Video
Updated: Apr 28, 2026
12:23
Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
9.9K
Midodrine-induced acute generalized exanthematous pustulosis
Mona Sadeghpour1, Christopher G Bunick, Deanne Mraz Robinson
1333 York St, HRT 618, New Haven, CT 06520, USA. mona.sadeghpour@gmail.com.
Cutis
|June 5, 2014
Summary
Acute generalized exanthematous pustulosis (AGEP) can be triggered by nonantibiotic drugs like midodrine. This rare condition may present with erythroderma and a delayed onset, differing from antibiotic-induced cases.
Area of Science:
- Dermatology
- Clinical Pharmacology
Background:
- Acute generalized exanthematous pustulosis (AGEP) is a rare, acute skin reaction characterized by sterile pustules.
- Medications are the most common triggers for AGEP, frequently including antibiotics.
Observation:
- A case study of a 58-year-old man presenting with AGEP and erythroderma after initiating midodrine therapy.
- Midodrine, a nonantibiotic medication, was identified as the likely causative agent.
Findings:
- This case highlights that nonantibiotic medications can induce AGEP.
- The onset of AGEP in this case was delayed compared to typical antibiotic-associated AGEP.
- Erythroderma was a prominent feature of the drug-induced AGEP.
Implications:
- Clinicians should consider nonantibiotic drugs, such as midodrine, in the differential diagnosis of AGEP.
- Awareness of delayed onset is crucial for diagnosing nonantibiotic-induced AGEP.
- This case expands the understanding of drug-induced dermatological reactions and their varied presentations.
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