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Updated: Apr 28, 2026
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A Neuroscientific Approach to the Examination of Concussions in Student-Athletes
Published on: December 8, 2014
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The neurophysiology of concussion
1Department of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, Calif., USA.
Progress in Neurological Surgery
|June 14, 2014
Summary
Concussion, or mild traumatic brain injury, triggers a neurobiological cascade leading to cellular energy crisis and neuronal dysfunction. This injury is not benign, increasing risks for long-term neurological issues.
Area of Science:
- Neurobiology
- Neurology
- Traumatic Brain Injury
Background:
- Concussion, also known as mild traumatic brain injury (mTBI), has complex neurobiological underpinnings.
- Historical research has illuminated the brain's response to this injury.
Purpose of the Study:
- To review the neurobiological response to concussion.
- To discuss the neurochemical and metabolic cascade following mild traumatic brain injury.
Main Methods:
- Review of experimental studies on concussion.
- Inclusion of relevant human observations for context.
Main Results:
- Concussion induces a neurochemical and metabolic cascade, creating a cellular energy crisis.
- Massive ionic flux, particularly involving potassium and calcium, drives metabolic demands and injury-induced diaschisis.
- Neuronal dysfunction and deficits result, increasing vulnerability to secondary insults and long-term problems.
Conclusions:
- Cerebral concussion is a significant event with lasting neuroscientific consequences.
- Symptoms and increased risk for central nervous system challenges are associated with concussion.
- Understanding the neurobiology of concussion is crucial for managing its effects.
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