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Related Concept Videos

Canonical Wnt Signaling Pathway02:54

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The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
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Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
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The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
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Updated: Apr 28, 2026

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
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Wnt signaling in osteosarcoma.

Carol H Lin1, Tao Ji, Cheng-Fong Chen

  • 1The Hyundai Cancer Institute, CHOC Children's Hospital, Orange, CA, USA.

Advances in Experimental Medicine and Biology
|June 14, 2014
PubMed
Summary
This summary is machine-generated.

Osteosarcoma (OS) is a common childhood bone cancer with poor prognosis. Targeting the Wnt/β-catenin pathway, crucial for OS progression, offers potential new therapies.

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Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Signaling Pathways

Background:

  • Osteosarcoma (OS) is the most frequent primary bone cancer in children and adolescents.
  • Current treatments offer limited improvement in prognosis, with 60-70% survival for localized disease.
  • Wnt signaling is critical for OS progression, regulating proliferation, cell fate, and differentiation.

Purpose of the Study:

  • To review current understanding of Wnt/β-catenin signaling in OS.
  • To discuss canonical and noncanonical Wnt pathways in OS.
  • To explore the role of stem cells and Wnt signaling in OS.

Main Methods:

  • Review of recent in vitro and in vivo data on Wnt/β-catenin signaling in OS.
  • Discussion of secreted protein families modulating Wnt signaling (sFRPs, WIF, DKKs, sclerostin).
  • Exploration of canonical and noncanonical Wnt pathways and their targets.

Main Results:

  • Wnt/β-catenin signaling is central to OS pathogenesis.
  • Several secreted proteins and small molecules modulate Wnt signaling in OS.
  • Noncanonical Wnt pathways and stem cell associations are relevant to OS.

Conclusions:

  • Wnt/β-catenin pathway inhibition is a potential therapeutic strategy for OS.
  • Further exploration of Wnt agonists and antagonists is needed for targeted therapies.
  • Understanding Wnt signaling complexity is key to improving OS patient outcomes.