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Related Concept Videos

Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

34
Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows...
34
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

1.5K
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
1.5K
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

1.6K
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
1.6K
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

27
Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal...
27
Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

29
Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The...
29
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

29
Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
29

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Chronic Salmonella Infection Induced Intestinal Fibrosis
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Published on: September 22, 2019

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Inflammatory bowel disease.

Daniele Corridoni1, Kristen O Arseneau1, Fabio Cominelli1

  • 1Department of Medicine, Case Western Reserve University, Cleveland, OH, USA; Digestive Health Research Center, Case Western Reserve University, Cleveland, OH, USA.

Immunology Letters
|June 19, 2014
PubMed
Summary
This summary is machine-generated.

Inflammatory bowel diseases (IBD), such as Crohn's disease and ulcerative colitis, involve complex immune responses. Animal models are crucial for understanding IBD causes and testing new treatments.

Keywords:
Animal modelsCrohn's diseaseCytokineInflammatory bowel diseaseUlcerative colitis

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Area of Science:

  • Gastroenterology and Immunology

Background:

  • Inflammatory bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), are chronic gastrointestinal inflammatory conditions.
  • The exact pathogenesis of IBD remains poorly understood, though it's linked to immune dysregulation in genetically susceptible individuals exposed to environmental factors.

Purpose of the Study:

  • To review key factors implicated in IBD pathogenesis.
  • To describe important animal models used in IBD research.

Main Methods:

  • Literature review of IBD pathogenesis.
  • Analysis of established IBD animal models.

Main Results:

  • IBD pathogenesis involves genetic susceptibility, environmental triggers, microbial factors, and host immune responses.
  • Various animal models exist, each with distinct features relevant to studying IBD.

Conclusions:

  • Understanding IBD requires examining genetic, environmental, and immune system interactions.
  • Animal models are essential for elucidating IBD mechanisms and evaluating therapeutic strategies.