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Related Experiment Video

Updated: Apr 28, 2026

In Vivo Tracking of Edema Development and Microvascular Pathology in a Model of Experimental Cerebral Malaria Using Magnetic Resonance Imaging
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Splenic infarction and malaria.

Francesca F Norman1, Jorge Rojas-Marcos2, José-Manuel Hermida-Donate2

  • 1Infectious Diseases Department, Ramón y Cajal Hospital, IRYCIS, Madrid, Spain Tropical Medicine and Clinical Parasitology Unit, Ramón y Cajal Hospital, IRYCIS, Madrid, Spain ffnorman@gmail.com.

Transactions of the Royal Society of Tropical Medicine and Hygiene
|June 20, 2014
PubMed
Summary

Splenic infarction, a rare malaria complication, often presents with fever and pain. Early identification and conservative management are key for favorable outcomes.

Keywords:
MalariaPlasmodium falciparumPlasmodium vivaxSplenic infarctionTraveller

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Area of Science:

  • Infectious Diseases
  • Tropical Medicine
  • Hematology

Background:

  • Splenic infarction is an infrequently reported complication of malaria.
  • Understanding its characteristics is crucial for diagnosis and management.

Purpose of the Study:

  • To review and describe the spectrum of characteristics associated with splenic infarction in malaria patients.
  • To inform clinical recognition and management strategies.

Main Methods:

  • A literature review was conducted.
  • Characteristics of reported splenic infarction cases were analyzed.

Main Results:

  • Common symptoms include fever, left upper quadrant pain, and splenomegaly.
  • Plasmodium vivax is often associated with autochthonous infections, while P. falciparum is linked to traveler cases.
  • No single symptom reliably predicts splenic infarction.

Conclusions:

  • Identifying splenic infarction aids in management recommendations and excluding complications like splenic rupture.
  • Conservative management is generally preferred with favorable outcomes.