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Updated: Apr 27, 2026
Lipidomics and Transcriptomics in Neurological Diseases
Published on: March 18, 2022
Proteomic approaches to dissect neuronal signaling pathways.
Heather L Bowling1, Katrin Deinhardt
1Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY, 10016, USA, Heather.Bowling@med.nyu.edu.
Understanding the brain requires exploring molecular mechanisms. This study uses proteomic techniques to investigate neurotrophins and antipsychotics, key modulators of neuronal function.
Area of Science:
- Neuroscience
- Molecular Biology
- Proteomics
Background:
- Growing awareness of mental health issues and neurological disorders highlights the need for deeper brain understanding.
- Research priorities include mapping brain connectivity, network activity, and underlying cellular/molecular processes.
Purpose of the Study:
- To elucidate molecular mechanisms of neuronal function modulators.
- To investigate the roles of neurotrophins and antipsychotics in brain function.
Main Methods:
- Utilized diverse proteomic techniques.
- Applied methods to analyze molecular underpinnings of neurotrophin and antipsychotic action.
Main Results:
- Detailed molecular mechanisms of neurotrophins were uncovered.
- Specific molecular pathways affected by antipsychotics were identified.
Conclusions:
- Proteomics offers powerful tools for understanding complex brain functions.
- This research advances knowledge of neurotrophins and antipsychotics, crucial for mental health and neurological disorder research.
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