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Related Concept Videos

Classification of Leukocytes01:30

Classification of Leukocytes

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Leukocytes are classified into two groups based on the presence or absence of cytoplasmic granules. Granular leukocytes, which contain granules, belong to the myeloid lineage and are divided into three subtypes: neutrophils, eosinophils, and basophils. These cells are roughly spherical and characterized by the granules in their cytoplasm.
Neutrophils are the most abundant type of granular leukocytes, comprising 50-70% of all leukocytes. They feature small, evenly distributed granules and a...
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Disorders of Leukocytes01:27

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Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
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HPLC-based Assay to Monitor Extracellular Nucleotide/Nucleoside Metabolism in Human Chronic Lymphocytic Leukemia Cells
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[Large granular lymphocyte leukemia].

Chao Xiao1, Xi Zhang1, Chun-Kang Chang1

  • 1Department of Hematology, Affiliated Sixth People Hospital, Shanghai Jiaotong University, Shanghai 200233, China.

Zhongguo Shi Yan Xue Ye Xue Za Zhi
|July 4, 2014
PubMed
Summary
This summary is machine-generated.

Large granular lymphocytic (LGL) leukemia encompasses T-cell LGL leukemia and NK-cell disorders. Treatment ranges from watchful waiting to intensive chemotherapy and stem cell transplant, depending on disease subtype and severity.

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Area of Science:

  • Hematology
  • Oncology
  • Immunology

Context:

  • Large granular lymphocytic (LGL) leukemia is a rare clonal lymphoproliferative disorder.
  • WHO classification identifies T-cell LGL leukemia (T-LGL) and chronic lymphoproliferative disorders of NK-cells (CLPD-NK).
  • Significant overlap exists between T-LGL and CLPD-NK in clinical presentation and management.

Purpose:

  • To review the pathogenesis, diagnosis, treatment, and prognosis of LGL leukemia subtypes.
  • To discuss current management strategies based on disease characteristics.
  • To highlight the challenges posed by the rarity of these conditions.

Summary:

  • LGL leukemia includes T-LGL, CLPD-NK, and aggressive NK-cell leukemia.
  • Asymptomatic patients often require no immediate treatment; immunosuppressive therapy is used for cytopenias.
  • Aggressive forms necessitate intensive chemotherapy and stem cell transplantation.

Impact:

  • Provides a comprehensive overview for clinicians managing LGL leukemia.
  • Aids in understanding the distinct clinical courses and treatment approaches for different LGL subtypes.
  • Highlights the need for further research and clinical trials due to the rarity of these leukemias.