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Psychiatric agents and implications for perioperative analgesia
Blas Catalani1, Craig S Hamilton1, Edwin W Herron1
1Department of Anesthesiology, Louisiana State University Health Sciences Center, Shreveport, LA, USA.
Best Practice & Research. Clinical Anaesthesiology
|July 5, 2014
Summary
Psychotropic medications like antidepressants and anxiolytics are increasingly used for pain relief during surgery. Understanding their complex effects and interactions is crucial for patient safety and optimal outcomes.
Area of Science:
- Anesthesiology
- Pharmacology
- Psychiatry
Background:
- Psychotropic medications (antidepressants, anxiolytics, mood stabilizers, anticonvulsants, tranquilizers) introduce complexities in perioperative care.
- These agents are increasingly prescribed for analgesia, even in patients without psychiatric diagnoses.
- Their precise analgesic mechanisms and dose-response relationships are often poorly understood.
Purpose of the Study:
- To review psychotropic agents used in the perioperative setting.
- To focus on their analgesic properties and clinical implications.
- To provide evidence-based recommendations for clinical practice.
Main Methods:
- Comprehensive review of current literature on psychotropic medications.
- Individualized analysis of various drug classes.
- Focus on analgesic effects, side effects, and drug interactions.
Main Results:
- Summary of the latest research on psychotropic agents' analgesic properties.
- Identification of knowledge gaps regarding their perioperative use.
- Discussion of potential side effects and drug interactions.
Conclusions:
- Familiarity with psychotropic medications' side effects and interactions is essential for safe perioperative management.
- Further research is needed to clarify mechanisms and optimize analgesic use.
- Evidence-based recommendations are provided for clinical practice.
Keywords:
adultanalgesic agentsanalgesic drugsanalgesicsanorexic drugsanorexigenic drugsanticonvulsantsantidepressive agentsantidepressive agents, tricyclicantipsychotic drugsanxiolyticsbarbituratesbenzodiazepinesbuspironecentral stimulantslithium carbonatemonoamine oxidase inhibitorsneuroleptanalgesianeuroleptic drugsneurotransmitter uptake inhibitorspainperioperative careperioperative periodpsychotropic drugsserotonin uptake inhibitors
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