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Total synthesis of (-)-crinipellin A
Taek Kang1, Seog Boem Song, Won-Yeob Kim
1Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST) , Daejeon, 305-701, Korea.
Journal of the American Chemical Society
|July 9, 2014
Abstract:
The first total synthesis of (-)-crinipellin A is described. The tetraquinane core skeleton of crinipellin A was assembled through the tandem [2 + 3] cycloaddition reaction of an allenyl diazo substrate containing a cyclopentane ring in a single operation. The absolute stereochemistry was confirmed through the total synthesis.