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Analytic morphomics corresponds to functional status in older patients
Ashley L Miller1, Lillian C Min2, Kathleen M Diehl3
1Department of Surgery, University of Michigan, Ann Arbor, Michigan; Department of Medicine, Division of Geriatric and Palliative Medicine, University of Michigan, Ann Arbor, Michigan.
The Journal of Surgical Research
|July 13, 2014
Summary
Older surgical patients with greater trunk muscle size (total psoas area) show better mobility, daily function, and cognitive ability. This objective measure aids in assessing surgical fitness in the elderly population.
Area of Science:
- Geriatric Medicine
- Surgical Oncology
- Radiology
Background:
- Older adults constitute a significant portion of surgical patients.
- Age alone is insufficient to predict surgical fitness.
- Objective risk assessment tools are needed for preoperative evaluation.
Purpose of the Study:
- To determine if analytic morphomics correlates with functional measures in older surgical patients.
- To assess the association between total psoas area (TPA) and geriatric functional domains.
Main Methods:
- Retrospective analysis of 184 elective general surgery patients aged over 70.
- Used analytic morphomics to calculate TPA from CT scans.
- Assessed TPA's relationship with mobility, activities of daily living (ADLs), and cognitive function using univariate logistic regression.
Main Results:
- Greater TPA was inversely correlated with impaired mobility (OR=0.46).
- Larger TPA was associated with decreased odds of deficits in basic (OR=0.36) and instrumental ADLs (OR=0.53).
- Increased TPA correlated with less cognitive difficulty (OR=0.55).
Conclusions:
- Greater trunk muscle size (TPA) in older surgical candidates is linked to better physical function, cognitive ability, and self-care.
- Analytic morphomics, specifically TPA, shows promise as an objective tool for preoperative risk assessment.
- Further research is required to connect these morphometric findings with clinical outcomes.
