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Updated: Apr 26, 2026

Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease
Published on: December 18, 2016
UTE imaging in the musculoskeletal system.
Eric Y Chang1, Jiang Du, Christine B Chung
1Department of Radiology, VA San Diego Healthcare System, San Diego, California, USA; Department of Radiology, University of California, San Diego Medical Center, San Diego, California, USA.
Ultrashort echo time (UTE) magnetic resonance imaging (MRI) sequences capture signals from musculoskeletal tissues with very short relaxation times. This review covers UTE sequence advancements and clinical applications for improved musculoskeletal imaging.
Area of Science:
- Biomedical Engineering
- Radiology
- Musculoskeletal Imaging
Background:
- Musculoskeletal tissues like bone, tendon, and ligaments exhibit short transverse relaxation times (T2/T2*).
- Conventional MRI sequences with long echo times (TE) fail to detect signals from these tissues due to rapid signal decay.
- This limitation hinders detailed imaging and quantitative analysis of crucial connective tissues.
Purpose of the Study:
- To review the development and modifications of the ultrashort echo time (UTE) sequence.
- To explore how UTE sequence advancements improve efficiency, contrast, and quantitative analysis.
- To highlight the clinical musculoskeletal applications of UTE sequences.
Main Methods:
- Review of ultrashort echo time (UTE) magnetic resonance imaging (MRI) sequence principles.
- Analysis of various UTE sequence modifications and their impact on signal acquisition.
- Compilation of clinical musculoskeletal applications demonstrating UTE's utility.
Main Results:
- UTE sequences enable signal detection from tissues with short and ultrashort T2/T2* relaxation times.
- Modifications to the UTE sequence have enhanced imaging efficiency and contrast.
- Quantitative analysis capabilities have been improved through UTE sequence development.
Conclusions:
- The UTE sequence is a vital tool for musculoskeletal MRI, overcoming limitations of conventional techniques.
- Ongoing modifications continue to expand the utility and applications of UTE in clinical practice.
- UTE imaging provides valuable insights into the composition and function of musculoskeletal tissues.
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