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Long non-coding RNA deregulation in tongue squamous cell carcinoma
Wei Gao1, Jimmy Yu-Wai Chan1, Thian-Sze Wong1
1Department of Surgery, LKS Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Kowloon, Hong Kong.
Biomed Research International
|July 22, 2014
Summary
This study identifies novel long non-coding RNAs (lncRNAs) in tongue squamous cell carcinoma (SCC). Deregulated lncRNAs are linked to tumor stage and nodal status, suggesting their role in SCC development.
Area of Science:
- Oncology
- Molecular Biology
- Genomics
Background:
- Deregulation of long non-coding RNAs (lncRNAs) is implicated in various cancers.
- Comprehensive studies on lncRNAs in tongue squamous cell carcinoma (SCC) are limited.
Purpose of the Study:
- To identify novel differentially expressed lncRNAs in tongue SCC.
- To investigate the association of lncRNAs with clinical parameters of tongue SCC.
Main Methods:
- Functional reannotation of human lncRNAs using the ncFANs algorithm.
- Validation of identified lncRNAs via real-time quantitative PCR.
- Analysis of lncRNA expression in relation to tumor stage and nodal status.
Main Results:
- Eight differentially expressed lncRNAs were identified in tongue SCC tissues.
- Specific lncRNAs (e.g., lnc-MBL2-4:3) were upregulated, while others (e.g., lnc-AL355149.1-1) were downregulated.
- lnc-MBL2-4:3 expression correlated with nodal positivity, and lnc-AL355149.1-1 with advanced T-stage.
Conclusions:
- Functional reannotation of existing datasets can identify novel lncRNAs.
- lncRNA deregulation is associated with tongue SCC pathogenesis, influencing T-stage and nodal status.
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