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Simple and robust saturation-based slice selection for ultrashort echo time MRI.

Kevin D Harkins¹, R Adam Horch^1,2, Mark D Does^1,2,3,4

¹Institute of Imaging Science, Vanderbilt University, Nashville, Tennessee, USA.

Magnetic Resonance in Medicine

|July 22, 2014

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Saturation-based ultrashort echo time (sat-UTE) imaging offers fast, quantitative evaluation of short T2 signals. This new method effectively localizes signals within a 2D slice, proving robust for various applications.

Area of Science:

Biomedical Engineering
Medical Imaging Physics

Background:

Ultrashort echo time (UTE) imaging is crucial for visualizing tissues with short T2 relaxation times.
Accurate signal localization within a 2D slice is essential for quantitative UTE analysis.

Purpose of the Study:

Introduce a novel slice-selective method for UTE imaging: saturation-based UTE (sat-UTE).
Develop a technique for precise signal localization within a 2D slice for UTE applications.

Main Methods:

Sat-UTE employs digital subtraction of two nonselective excitations: one with and one without selective slice saturation.
Validation involved comparisons with existing UTE methods (half-pulse, double-half pulse, 3D-UTE) in phantoms, ex vivo femur, and in vivo tibia.
Numerical simulations quantified slice profile effects and signal component amplitudes for quantitative UTE.

Keywords:

2D UTE saturation slice selective ultrashort echo time

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Main Results:

Sat-UTE demonstrated robustness in suppressing out-of-slice signals.
The method produced short T2 signal decay curves comparable to 3D-UTE.
Signal-to-noise ratio efficiency was lower compared to other slice-selective UTE techniques.

Conclusions:

Sat-UTE provides a valuable tool for rapid, quantitative assessment of short T2 signals.
The technique is insensitive to variations in gradient performance, enhancing its reliability.