[HIV-associated non-AIDS conditions].

Area of Science:

• Infectious Diseases
• Immunology
• Public Health

Context:

• Antiretroviral therapy (ART) has significantly improved life expectancy and quality of life for individuals with HIV.
• Mortality rates have declined, and opportunistic diseases are less common in the HIV-positive population.
• The changing health landscape necessitates a re-evaluation of HIV care paradigms.

Purpose:

• To describe the evolving patterns of mortality and morbidity among individuals receiving ART.
• To highlight the shift in clinical focus towards ART-related issues and non-AIDS comorbidities.
• To underscore the critical role of primary care in managing complex HIV-related conditions.

Summary:

• HIV treatment advancements have led to a decrease in AIDS-defining illnesses and an increase in life expectancy.
• The primary causes of illness and death are shifting towards non-AIDS related conditions and ART toxicities.
• These comorbidities arise from long-term ART, chronic HIV inflammation, lifestyle factors, and aging.

Impact:

• The increasing prevalence of non-AIDS comorbidities emphasizes the need for comprehensive management strategies.
• Primary care physicians, particularly those experienced in HIV, are essential in addressing these complex health challenges.
• This shift necessitates enhanced collaboration between infectious disease specialists and primary care providers for optimal patient outcomes.