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Related Experiment Video

Updated: Apr 26, 2026

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291
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[Clostridium difficile ribotype 027 is a challenge].

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Summary

A Clostridium difficile (C. diff) outbreak in Denmark affected elderly patients, with a high mortality rate. Further research is crucial to minimize C. diff infections and improve treatment strategies.

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Area of Science:

  • Infectious Diseases
  • Epidemiology
  • Medical Microbiology

Background:

  • Clostridium difficile infection (CDI) is a leading cause of antibiotic-associated diarrhea.
  • A significant CD027 outbreak occurred in North Zealand, Denmark, in 2008.

Purpose of the Study:

  • To describe the characteristics of Clostridium difficile infections in a single medical department during an outbreak.
  • To analyze demographic data and outcomes of affected patients.

Main Methods:

  • Retrospective study including patients positive for C. difficile.
  • Data collection from Medical Department O, Herlev Hospital, in 2009.
  • Inclusion of 69 patients, recording demographic data and Charlson Comorbidity Score.

Main Results:

  • The study included 69 patients with an average age of 83 years.
  • The average Charlson Comorbidity Score was 4, indicating significant comorbidities.
  • A total of 24 patients (34.8%) died during the study period.

Conclusions:

  • Clostridium difficile infections pose a significant threat, particularly to elderly patients with comorbidities.
  • The high mortality observed underscores the need for effective treatment and prevention strategies.
  • Further research is essential to minimize the impact of C. difficile infections.