Related Experiment Video
Updated: Apr 26, 2026

Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies
Published on: September 15, 2023
On statistical relationship between ADRA2A expression and the risk of breast cancer relapse
M Yu Shkurnikov1, V V Galatenko, A E Lebedev
1Research Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia.
Abstract:
The search for novel parameters to predict the risk of relapse in breast cancer was conducted. Significant correlation between the risk of relapse and α-2A adrenergic receptor (ADRA2A) expression was revealed using public microarray datasets. This relationship was confirmed by validation on independent microarray dataset. It was found that when assessing the risk of BC relapse, the accuracy of prediction based solely on the expression of ADRA2A gene is close to that made using OncotypeDX and MammaPrint test systems. In this case, addition of only one or two supplemental prognostic markers (for instance, expression of SQLE gene or SQLE and DSCC1genes) to ADRA2A ensures the accuracy of prediction not inferior to reliability of these test systems.
More Related Videos
Related Concept Videos
Cancer Survival Analysis
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase
Psychoneuroimmunology: Diabetes and Cancer
mTOR Signaling and Cancer Progression
The mTOR pathway or the...

