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Effect of duplicate genes on mouse genetic robustness: an update
Zhixi Su1, Junqiang Wang1, Xun Gu2
1State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai 200433, China.
Biomed Research International
|August 12, 2014
Summary
Duplicate genes significantly impact mouse genetic robustness, contrary to previous findings. This effect is dependent on the age of gene duplication, resolving the "knockout duplicate puzzle".
Area of Science:
- Genetics
- Evolutionary Biology
Background:
- Previous analyses of mouse knockout (KO) data suggested duplicate genes have minimal impact on genetic robustness.
- The
Purpose of the Study:
- To re-evaluate the role of duplicate genes in mouse genetic robustness using extensive KO phenotype data.
- To investigate the influence of duplication age on this role.
Main Methods:
- Comprehensive analysis of mouse KO phenotype data.
- Statistical analysis to rule out confounding factors like coding-sequence conservation, protein-protein connectivity, functional bias, and whole genome duplication (WGD) bias.
Main Results:
- Duplicate genes have a significant effect on mouse genetic robustness.
- This effect is dependent on the age of gene duplication.
- The study identified sampling bias toward ancient duplicates as a cause of the previous
Conclusions:
- The
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