Related Experiment Video
Updated: Apr 26, 2026
05:39
Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
Published on: May 16, 2025
928
[Prurigo nodularis: its association with dermatoses and systemic disorders]
1Fachbereich Nephrologie, DKD Helios Kliniken Wiesbaden, Aukammallee 33, 65191, Wiesbaden, Deutschland, mettang@nephrologie-wiesbaden.de.
Summary
Prurigo nodularis is a skin condition linked to chronic itching from various diseases. An interdisciplinary approach is vital for diagnosing and treating this challenging condition.
Area of Science:
- Dermatology
- Internal Medicine
- Neurology
Context:
- Prurigo manifests in diverse dermatological, systemic, and neurological conditions.
- Prurigo nodularis is frequently associated with atopic dermatitis, cutaneous lymphomas, and mycobacterial skin infections.
- Systemic associations include chronic renal or hepatic diseases, hematological disorders, and metabolic conditions like diabetes mellitus.
Purpose:
- To identify diseases associated with prurigo nodularis across dermatology, internal medicine, and neurology.
- To explore the pathogenetic mechanisms and therapeutic strategies for prurigo nodularis.
Summary:
- Prurigo nodularis presents as a skin manifestation of chronic pruritus.
- Frequently linked to atopic dermatitis, systemic diseases (renal, hepatic, hematological, metabolic), and neurological disorders.
- Pathophysiology is partially understood; treatment requires a multimodal, interdisciplinary approach.
Impact:
- Highlights the multifactorial nature of prurigo nodularis.
- Emphasizes the need for comprehensive diagnostic and therapeutic strategies.
- Promotes an interdisciplinary approach for improved patient outcomes in managing prurigo nodularis.
More Related Videos
10:27Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
Published on: December 15, 2011
23.9K
08:33Targeting Alpha Synuclein Aggregates in Cutaneous Peripheral Nerve Fibers by Free-floating Immunofluorescence Assay
Published on: June 25, 2019
7.7K
Related Concept Videos
01:23Skin Diseases and Disorders
5.1K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
5.1K
01:28Graves' Disease I: Introduction
15
Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence...
15
01:29Autoimmune Disorders
2.3K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
2.3K
01:33Pleiotropy
31.2K
Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
31.2K
01:30Skin Cancer
5.2K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
5.2K
01:16Primary Lymphoid Organs
9.6K
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
9.6K