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Pelger-Huët anomaly in a cat
Pierre Deshuillers1, Rose Raskin, Joanne Messick
1Department of Comparative Pathobiology, Purdue University College of Veterinary Medicine, West Lafayette, IN, USA.
Veterinary Clinical Pathology
|August 14, 2014
Summary
A cat diagnosed with hyperthyroidism exhibited Pelger-Huët anomaly, a rare inherited condition affecting white blood cells. This finding in a feline patient highlights the importance of careful hematological evaluation alongside other diagnostics.
Area of Science:
- Veterinary Hematology
- Canine and Feline Medicine
- Inherited Hematological Disorders
Background:
- Hyperthyroidism is a common endocrine disorder in older cats.
- Iodine-131 (I-131) therapy is a standard treatment for feline hyperthyroidism.
- Pelger-Huët anomaly is a rare, inherited disorder affecting neutrophil maturation.
Observation:
- A 14-year-old spayed female Domestic Shorthair cat presented for I-131 treatment.
- Hematological examination revealed hyposegmented neutrophils and eosinophils with mature chromatin.
- Nuclear morphology suggested Pelger-Huët anomaly or a pseudo Pelger-Huët anomaly.
Findings:
- The cat tested negative for Feline Leukemia Virus (FeLV) and Feline Immunodeficiency Virus (FIV).
- No clinical signs of inflammation were present.
- The persistent granulocytic morphology over six months confirmed the diagnosis of Pelger-Huët anomaly.
Implications:
- This case highlights the importance of recognizing Pelger-Huët anomaly in feline hematology.
- Accurate diagnosis is crucial to differentiate from acquired conditions like pseudo Pelger-Huët anomaly.
- Understanding this anomaly aids in interpreting hematological findings in cats undergoing treatment for other conditions.
