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Acute paraplegia during weightlifting: an unusual vascular catastrophe

Rushi V Parikh1, Farzad Alemi1, Daniel R Kievlan1

  • 1Departments of Medicine (Dr. Parikh), Surgery (Dr. Alemi), and Emergency Medicine (Dr. Kievlan), University of California, San Francisco, San Francisco, California 94131; and Departments of Radiology (Dr. Vu) and Medicine (Dr. Barnett), San Francisco General Hospital, University of California, San Francisco, California 94110.

Texas Heart Institute Journal
|August 15, 2014
PubMed
Abstract

No abstract available in PubMed .

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Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...
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