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Arfs at a glance.

Catherine L Jackson1, Samuel Bouvet2

  • 1Membrane Dynamics and Intracellular Trafficking, Institut Jacques Monod, CNRS, UMR 7592, Université Paris Diderot, Sorbonne Paris Cité, F-75013 Paris, France jackson@ijm.univ-paris-diderot.fr.

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|August 23, 2014
PubMed
Summary
This summary is machine-generated.

Arf small G proteins control cellular transport of proteins and lipids. Their regulators, GEFs and GAPs, ensure precise control, impacting various cellular functions and disease states.

Keywords:
Arf small GTP-binding proteinGolgiLipid transportMembrane contact sitePlasma membraneVesicle trafficking

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Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Arf small G proteins are key regulators of intracellular trafficking.
  • They cycle between GTP- and GDP-bound states, influencing effector recruitment.
  • Dysregulation of Arf proteins is implicated in various diseases.

Purpose of the Study:

  • To review the fundamental roles of Arf proteins in cellular trafficking.
  • To highlight the regulatory mechanisms involving GEFs and GAPs.
  • To discuss the involvement of Arf proteins in human diseases and pathogen interactions.

Main Methods:

  • Literature review and synthesis of existing research.
  • Analysis of Arf protein functions in vesicle formation, lipid transport, and cytoskeletal regulation.
  • Examination of Arf protein modulation by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs).

Main Results:

  • Arf proteins recruit effectors in their GTP-bound state, driving vesicle trafficking and lipid transport.
  • GEFs and GAPs provide spatiotemporal control over Arf activity.
  • Arf proteins are involved in diverse cellular processes including mitosis and signaling.

Conclusions:

  • Arf proteins are central to membrane trafficking and lipid homeostasis.
  • Their regulation by GEFs and GAPs is critical for cellular function.
  • Understanding Arf pathways offers insights into disease mechanisms and potential therapeutic targets.