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Updated: Apr 25, 2026

A Method for Characterizing Embryogenesis in Arabidopsis
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[Does embryo morphology constitute a reliable criterion for embryo selection?].

E Scalici1, A Gala2, A Ferrières3

  • 1Inserm U1040, département de biologie de la reproduction, hôpital Arnaud-de-Villeneuve, CHU de Montpellier, 371, avenue du Doyen-Gaston-Giraud, 34295 Montpellier, France; Inserm U1040, institut de médecine régénérative et biothérapie, hôpital Saint-Éloi, CHU de Montpellier, 80, avenue Augustin-Fliche, 34295 Montpellier, France; Université Montpellier 1, UFR de médecine, 34000 Montpellier, France.

Gynecologie, Obstetrique & Fertilite
|August 26, 2014
PubMed
Summary
This summary is machine-generated.

Embryo selection using only morphology or time-lapse imaging has limitations. New non-invasive "omics" approaches aim to identify biomarkers for better prediction of embryo quality and pregnancy success in assisted reproduction.

Keywords:
Critères morphocinétiquesEmbryo morphologyFécondation in vitroIn vitro fertilizationMorphokinetics criteriaMorphologie embryonnaireOmicsSystème time-lapseTime-lapse system

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Area of Science:

  • Reproductive biology
  • Biomarker discovery
  • Assisted reproductive technology (ART)

Context:

  • Current embryo selection methods, relying on morphology or time-lapse imaging, yield suboptimal implantation rates.
  • The clinical utility and cost-effectiveness of time-lapse systems require further validation through rigorous trials.
  • Existing methods highlight the need for advanced techniques to improve in vitro fertilization (IVF) outcomes.

Purpose:

  • To explore the limitations of current embryo assessment techniques in assisted reproductive technology.
  • To introduce and advocate for novel, non-invasive "omics" approaches for biomarker identification.
  • To enhance the prediction of oocyte and embryo quality, ultimately improving pregnancy rates.

Summary:

  • Morphological and morphokinetic assessments of embryos have inherent limitations in predicting implantation success.
  • Non-invasive "omics" strategies are proposed to identify biomarkers in the oocyte microenvironment or culture medium.
  • These biomarkers are intended to predict oocyte/embryo quality and pregnancy outcomes in ART.

Impact:

  • These "omics" approaches promise to revolutionize embryo viability assessment.
  • Development of new diagnostic and prognostic tests for improved IVF success rates.
  • Potential for personalized medicine in assisted reproduction through biomarker-based strategies.