Related Experiment Video
Updated: Apr 25, 2026
08:43
Investigating Intestinal Inflammation in DSS-induced Model of IBD
Published on: February 1, 2012
67.0K
[Functional diarrhea - pathophysiology, investigation and treatment]
1Abteilung für Gastroenterologie und Hepatologie, Universitätsspital Basel.
Therapeutische Umschau. Revue Therapeutique
|August 27, 2014
Summary
Diarrhea-predominant irritable bowel syndrome (IBS) causes chronic diarrhea and abdominal pain. Understanding its complex causes, like visceral hypersensitivity and gut motility issues, is key to effective, individualized treatment strategies.
Area of Science:
- Gastroenterology
- Functional Bowel Disorders
Context:
- Diarrhea-predominant irritable bowel syndrome (IBS) is a common cause of functional diarrhea.
- Characterized by chronic, intermittent diarrhea and abdominal pain.
Purpose:
- To provide an overview of the pathophysiology, diagnostic investigations, and treatment of IBS.
- To highlight the complexity of IBS etiology.
Summary:
- IBS pathophysiology involves visceral hypersensitivity, altered gut motility, and autonomic nervous system dysfunction.
- Genetic and psychosocial factors also contribute to IBS development.
- Treatment requires a personalized approach, integrating general measures, pharmacotherapy, diet, psychotherapy, and alternative therapies.
Impact:
- Improved understanding of IBS pathophysiology can lead to more targeted treatments.
- Personalized management strategies can enhance patient outcomes and quality of life.
- This overview serves as a guide for clinicians managing patients with functional diarrhea.
Related Concept Videos
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
1.1K
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
1.1K
01:23Irritable Bowel Syndrome
25
DefinitionIrritable bowel syndrome (IBS) is a functional gastrointestinal disorder characterized by recurrent combinations of abdominal pain, bloating, diarrhea, or constipation.Pathophysiology of irritable bowel syndromeIts pathophysiology is multifactorial, involving disturbances in motility, sensory processing, microbial balance, barrier integrity, and gut–brain communication. These mechanisms interact to produce symptoms that vary across IBS subtypes.Altered Motility...
25
01:17Drugs for Treatment of Diarrhea-Predominant IBS
996
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
996
01:30Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
1.0K
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
1.0K
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
1.5K
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
1.5K
01:20Drugs Affecting GI Tract Motility: Adsorbents as Antidiarrheal Agents
830
Diarrhea is characterized by the occurrence of frequent, watery bowel movements. Various factors can trigger diarrhea, including viral or bacterial infections, foodborne illnesses, side effects from certain medications, and underlying digestive disorders. If not adequately managed, diarrhea can lead to complications such as dehydration, electrolyte imbalances, and nutrient deficiencies. Severe diarrhea can lead to significant weight loss, malnutrition, and weakened immune function.
Adsorbents...
Adsorbents...
830