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Related Concept Videos

In Vitro Fertilization01:24

In Vitro Fertilization

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In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
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Fertilization01:38

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During fertilization, an egg and sperm cell fuse to create a new diploid structure. In humans, the process occurs once the egg has been released from the ovary, and travels into the fallopian tubes. The process requires several key steps: 1) sperm present in the genital tract must locate the egg; 2) once there, sperm need to release enzymes to help them burrow through the protective zona pellucida of the egg; and 3) the membranes of a single sperm cell and egg must fuse, with the sperm...
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Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for...
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In-situ Hybridization02:31

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In situ hybridization (ISH) is a technique used to detect and localize specific DNA or RNA molecules in cells, tissue, or tissue sections using a labeled probe. The technique was first used in 1969 for the investigation of nucleic acids. It is currently an essential tool in scientific research and clinical settings, especially for diagnostic purposes.
Types of probes and labels
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Related Experiment Video

Updated: Apr 25, 2026

Collection of Human Follicular Fluid, Follicle Somatic Cells, and Immature Oocytes from Individuals Undergoing In Vitro Fertilization
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[Circulating nucleic acids and in vitro fertilization].

E Scalici1, S Traver2, T Mullet3

  • 1Inserm U1040, institut de médecine régénérative et biothérapie, hôpital Saint-Éloi, CHU de Montpellier, 80, avenue Augustin-Fliche, 34295 Montpellier, France; Département de biologie de la reproduction, hôpital Arnaud-de-Villeneuve, CHU de Montpellier, 371, avenue du Doyen-Gaston-Giraud, 34295 Montpellier, France; Université Montpellier 1, UFR de médecine, 34000 Montpellier, France.

Gynecologie, Obstetrique & Fertilite
|August 27, 2014
PubMed
Summary
This summary is machine-generated.

Circulating nucleic acids like microRNAs and cell-free DNA show promise as biomarkers for infertility care and in vitro fertilization success. These molecules detected in blood could enhance diagnosis and prognosis for reproductive health.

Keywords:
ADN libreAcides nucléiques circulantsCell-free DNACirculating nucleic acidsEmbryo qualityFécondation in vitroImplantationIn vitro fertilizationMicroARNsMicroRNAsOvarian reserveQualité embryonnaireRéserve ovarienne

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Area of Science:

  • Reproductive biology
  • Molecular diagnostics
  • Biomarker discovery

Context:

  • Circulating nucleic acids (microRNAs, cell-free DNA) are established biomarkers in oncology and prenatal testing.
  • Research is exploring microRNAs within ovarian follicles and their role in folliculogenesis.
  • These biomarkers are increasingly recognized for their potential in various medical specialities.

Purpose:

  • To explore the utility of circulating nucleic acids as biomarkers in human reproduction.
  • To evaluate microRNAs and cell-free DNA for infertility diagnosis and prognosis.
  • To assess their potential in predicting oocyte/embryo quality and in vitro fertilization (IVF) outcomes.

Summary:

  • MicroRNAs and cell-free DNA are detectable in blood and can be linked to ovarian function and reproductive health.
  • Quantification of cell-free DNA may aid in evaluating ovarian functional status.
  • These circulating nucleic acids show potential as predictive biomarkers for oocyte and embryo quality, and for preventing IVF implantation failures.

Impact:

  • Circulating nucleic acids offer a pathway for developing innovative diagnostic and prognostic tests in reproductive medicine.
  • These advancements could significantly improve outcomes for individuals undergoing in vitro fertilization.
  • This research highlights a promising future for non-invasive biomarker-based approaches in fertility care.