Related Experiment Videos
Insulin secretion in childhood obesity
Acta Paediatrica Japonica : Overseas Edition
|October 1, 1989
Summary
Severely obese children show varying insulin responses, with some exhibiting impaired glucose metabolism. This suggests differences in insulin receptor sensitivity, highlighting obesity and family history as key diabetes mellitus risk factors.
Area of Science:
- Pediatrics
- Endocrinology
- Metabolic Disorders
Background:
- Severe obesity in children is a growing concern.
- Understanding glucose metabolism in obese children is crucial for early diabetes mellitus detection.
- Insulin resistance is a common feature of pediatric obesity.
Purpose of the Study:
- To investigate glucose metabolism and insulin levels in severely obese children.
- To identify risk factors for diabetes mellitus in this population.
- To explore the relationship between insulin secretion, obesity, and age.
Main Methods:
- Oral glucose tolerance tests were performed on 132 severely obese children.
- Children were categorized based on insulin levels (normal vs. high) and diabetes mellitus (DM) status.
- Correlation analysis was used to assess relationships between insulin levels, obesity index, and age.
Main Results:
- 64 out of 132 children had high insulin levels; 10 were diagnosed with diabetes mellitus, and 19 were suspected.
- Glucose metabolism varied, with some children showing incomplete or impossible metabolism even with high insulin levels.
- A moderate positive correlation was observed between insulin levels (sigma IRI) and obesity index/age.
Conclusions:
- Severely obese children exhibit diverse insulin secretion and glucose metabolism patterns.
- Differences in insulin receptor sensitivity may play a role in glucose intolerance.
- Age, severe obesity, and family history of diabetes mellitus are significant risk factors.