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Published on: March 11, 2017
Novel encapsulation systems and processes for overcoming the challenges of polypharmacy
Mine Orlu-Gul1, Ahmet Alptekin Topcu2, Talayeh Shams2
1School of Pharmacy, University College London, 29/39 Brunswick Square, London WC1N 1AX, UK.
Abstract:
The encapsulation process has been studied to develop smart drug delivery systems for decades. In particular, micro-encapsulation and nano-encapsulation approaches have gained wide interest in the development of particulate drug delivery and achieved progress in specialties such as nano-medicine. Encapsulation technologies have evolved through various platforms including emulsion solvent evaporation, spray drying and polymer conjugation. Among current encapsulation methods, electrohydrodynamic and microfluidic processes stand out by enabling the making of formulations with uniform shape and nanoscale size. Pressurized gyration is a new method of combining rotation and controlled pressure to produce encapsulated structures of various morphologies. In this review we address key developments in electrohydrodynamic, microfluidic, their combined and new approaches as well as their potential to obtain combined therapies with desired drug release profiles.
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