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Updated: Apr 24, 2026

Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
Published on: June 13, 2022
C-H activation guided by aromatic N-H ketimines: synthesis of functionalized isoquinolines using benzyl azides and
Sreya Gupta1, Junghoon Han, Yongjin Kim
1Department of Chemistry, POSTECH (Pohang University of Science and Technology) , Pohang, 790-784, Republic of Korea.
Abstract:
Aromatic N-H ketimines were in situ generated from various benzylic azides by ruthenium catalysis for the subsequent Rh-catalyzed annulation reaction with alkynes to give the corresponding isoquinolines. In contrast to conventional synthetic methods for aromatic N-H ketimines, our protocol works under mild and neutral conditions, which enabled the synthesis of isoquinolines having various functionalities such as carbonyl, ester, alkenyl, and ether groups. In addition, the imidates generated from α-azido ethers were successfully used for the synthesis of 1-alkoxyisoquinolines.
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