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Related Concept Videos

Diabetic Neuropathy01:22

Diabetic Neuropathy

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DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...
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Diabetic Foot Ulcer01:31

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Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory...
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Diabetes: Symptoms, Diagnosis, and Complications01:15

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For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
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Diabetic Retinopathy01:27

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DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
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Type I Diabetes III: Clinical Manifestations01:19

Type I Diabetes III: Clinical Manifestations

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Type 1 diabetes mellitus typically presents with rapid-onset symptoms due to the body’s inability to utilize glucose in the absence of insulin. Since insulin is required for glucose uptake into cells, its deficiency leads to hyperglycemia and cellular energy deprivation, resulting in characteristic clinical features.Polyuria and PolydipsiaOne of the earliest, most prominent symptoms is polyuria (excessive urination). When blood glucose concentrations rise above the renal threshold, the...
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Type I Diabetes II: Pathophysiology01:26

Type I Diabetes II: Pathophysiology

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Type 1 diabetes mellitus arises from an immune-mediated destruction of pancreatic β-cells, resulting in an absolute deficiency of insulin. This process develops in genetically susceptible individuals when autoimmunity, environmental exposures, and immunologic dysregulation converge to trigger a targeted attack on the insulin-producing cells of the pancreas. The β-cells are located within the islets of Langerhans and are essential for regulating blood glucose by facilitating cellular...
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Diabetic hands: a study on strength and function.

Fernanda de Carvalho e Silva1, Fernanda O Jakimiu1, Thelma L Skare1

  • 1Rheumatology Unit, Hospital Universitário Evangélico de Curitiba, PR, Brazil.

Diabetes & Metabolic Syndrome
|September 16, 2014
PubMed
Summary

Type 2 diabetes mellitus (DM) patients show impaired hand strength and function compared to controls. Stiffness and disease duration significantly impact hand function in these patients.

Keywords:
Carpal tunnel syndromeDiabetes mellitusHand functionHand strengthTendinitis

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Area of Science:

  • Rheumatology
  • Endocrinology
  • Hand Surgery

Background:

  • Type 2 diabetes mellitus (DM) is a systemic disease affecting multiple organs.
  • Hand complications are common in DM, impacting quality of life.
  • Limited research exists on specific hand strength and function deficits in type 2 DM.

Purpose of the Study:

  • To evaluate and compare hand strength and function in patients with type 2 DM.
  • To identify factors associated with hand strength and function impairment in type 2 DM.
  • To compare hand function in type 2 DM patients with those suffering from hand osteoarthritis and healthy controls.

Main Methods:

  • A comparative study involving 100 type 2 DM patients, 100 hand osteoarthritis patients, and 100 controls.
  • Data collection included hand strength, hand function, disease duration, glycemic control (HbA1C), creatinine levels, pain, and stiffness.
  • Physical examination was performed on all participants.

Main Results:

  • Type 2 DM patients demonstrated reduced hand strength and function compared to controls, but better than osteoarthritis patients.
  • Univariate analysis revealed associations between hand strength and De Quervain tendonitis (p=0.005).
  • Hand function was associated with carpal tunnel syndrome, De Quervain tendonitis, HbA1C, insulin use, disease duration, pain, and stiffness. Multivariate analysis identified disease duration and stiffness as significant factors.

Conclusions:

  • Hand strength and function are demonstrably impaired in individuals with type 2 DM.
  • Loss of hand function in type 2 DM is significantly linked to increased disease duration and stiffness.
  • Reduced hand strength is associated with De Quervain tendonitis in type 2 DM patients.