Preparation TiO2 core-shell nanospheres and application as efficiency drug detection sensor.

Area of Science:

• Materials Science
• Nanotechnology
• Analytical Chemistry

Background:

• Development of advanced nanomaterials for sensitive and selective chemical sensing is crucial.
• Titanium dioxide (TiO2) nanostructures offer unique properties for various applications.
• Electroactive complexes can enhance the performance of sensing platforms.

Purpose of the Study:

• To facilely prepare monodisperse titanium dioxide-diltiazem/tetrachlorobismuth core-shell nanospheres (TiO2@DTMBi).
• To investigate the structural and morphological characteristics of the synthesized nanospheres.
• To evaluate the efficacy of TiO2@DTMBi nanospheres as a sensor for diltiazem detection.

Main Methods:

• Synthesis of TiO2@DTMBi core-shell nanospheres using diltiazem (DTM)/tetrachlorobismuth (BiCl4) complexes.
• Characterization using transmission electron microscopy (TEM), scanning electron microscopy (SEM), dynamic light scattering (DLS), Fourier transform infrared spectroscopy (FTIR), and X-ray diffraction (XRD).
• Optimization of synthesis conditions for monodisperse 40-nm TiO2@DTMBi spheres.
• Electrochemical sensing performance evaluation for diltiazem detection.

Main Results:

• Successful preparation of monodisperse TiO2@DTMBi core-shell nanospheres.
• Comprehensive characterization confirmed the morphology, size, formation, and structure of the nanospheres.
• The TiO2@DTMBi nanospheres demonstrated a wide linear range for diltiazem detection from 10(-7) to 10(-1) M.
• A very low detection limit of 0.20 μg/mL was achieved for diltiazem.

Conclusions:

• The facile synthesis method yields monodisperse TiO2@DTMBi core-shell nanospheres with desirable properties.
• These nanospheres show significant potential as highly sensitive and effective sensors for diltiazem.
• The developed sensor platform offers a promising analytical tool for drug monitoring and detection.