Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

2.4K
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
2.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Mouse Model of Tuberculosis: Uses and Abuses.

Cold Spring Harbor perspectives in medicine·2026
Same author

First impressions count in TB.

The Journal of experimental medicine·2025
Same author

Altered hepatic metabolic landscape and insulin sensitivity in response to pulmonary tuberculosis.

PLoS pathogens·2024
Same author

Immunogenicity of PE18, PE31, and PPE26 proteins from <i>Mycobacterium tuberculosis</i> in humans and mice.

Frontiers in immunology·2023
Same author

A Persistent Tuberculosis Outbreak in the UK Is Characterized by Hydrophobic <i>fadB4</i>-Deficient <i>Mycobacterium tuberculosis</i> That Replicates Rapidly in Macrophages.

mBio·2022
Same author

Effect of high intensity interval training and moderate intensity continuous training on lymphoid, myeloid and inflammatory cells in kidney transplant recipients.

Exercise immunology review·2022
Same journal

The Biology of Malaria Parasite Liver Infection.

Cold Spring Harbor perspectives in medicine·2026
Same journal

The Interaction between Diabetes Mellitus and Tuberculosis: Epidemiology, Screening, and Clinical Management.

Cold Spring Harbor perspectives in medicine·2026
Same journal

New Malaria Prevention Modalities: Long-Acting Interventions Beyond Vaccines.

Cold Spring Harbor perspectives in medicine·2026
Same journal

From Parasite to Pill: Harnessing Biology for Breakthroughs in Antimalarial Drug Discovery.

Cold Spring Harbor perspectives in medicine·2026
Same journal

Malaria Parasite Genomics: Decentralization, Diversification, and Development Goals.

Cold Spring Harbor perspectives in medicine·2026
Same journal

Tuberculosis Infection: Diagnosis and Management.

Cold Spring Harbor perspectives in medicine·2026
See all related articles

Related Experiment Video

Updated: Apr 23, 2026

Use of the Invertebrate Galleria mellonella as an Infection Model to Study the Mycobacterium tuberculosis Complex
09:23

Use of the Invertebrate Galleria mellonella as an Infection Model to Study the Mycobacterium tuberculosis Complex

Published on: June 30, 2019

11.0K

Mouse model of tuberculosis.

Andrea M Cooper1

  • 1Trudeau Institute, Inc., Saranac Lake, New York 12983.

Cold Spring Harbor Perspectives in Medicine
|September 27, 2014
PubMed
Summary
This summary is machine-generated.

Mice models help study Mycobacterium tuberculosis (Mtb) interactions with the immune system. Understanding these complex immune responses is key to developing better tuberculosis treatments.

More Related Videos

Imaging Mycobacterium tuberculosis in Mice with Reporter Enzyme Fluorescence
10:06

Imaging Mycobacterium tuberculosis in Mice with Reporter Enzyme Fluorescence

Published on: February 26, 2018

8.2K
An Experimental Model to Study Tuberculosis-Malaria Coinfection upon Natural Transmission of Mycobacterium tuberculosis and Plasmodium berghei
09:02

An Experimental Model to Study Tuberculosis-Malaria Coinfection upon Natural Transmission of Mycobacterium tuberculosis and Plasmodium berghei

Published on: February 17, 2014

21.3K

Related Experiment Videos

Last Updated: Apr 23, 2026

Use of the Invertebrate Galleria mellonella as an Infection Model to Study the Mycobacterium tuberculosis Complex
09:23

Use of the Invertebrate Galleria mellonella as an Infection Model to Study the Mycobacterium tuberculosis Complex

Published on: June 30, 2019

11.0K
Imaging Mycobacterium tuberculosis in Mice with Reporter Enzyme Fluorescence
10:06

Imaging Mycobacterium tuberculosis in Mice with Reporter Enzyme Fluorescence

Published on: February 26, 2018

8.2K
An Experimental Model to Study Tuberculosis-Malaria Coinfection upon Natural Transmission of Mycobacterium tuberculosis and Plasmodium berghei
09:02

An Experimental Model to Study Tuberculosis-Malaria Coinfection upon Natural Transmission of Mycobacterium tuberculosis and Plasmodium berghei

Published on: February 17, 2014

21.3K

Area of Science:

  • Immunology
  • Microbiology
  • Infectious Diseases

Background:

  • Mycobacterium tuberculosis (Mtb) is a persistent bacterium causing inflammation.
  • The mammalian immune system's interaction with Mtb is complex.
  • Mouse models have been used to study Mtb infection.

Purpose of the Study:

  • To dissect the complex interactions within the immune response to Mtb.
  • To delineate the pathways of specific molecules and cells in Mtb infection.
  • To improve intervention strategies for tuberculosis.

Main Methods:

  • Utilizing mouse models for Mtb infection studies.
  • Employing genetic deletion and antibody inhibition techniques.
  • Correlating mouse model findings with human observations.

Main Results:

  • Mouse models have identified links between immune components and Mtb survival.
  • Studies show correspondence between mouse and human responses to Mtb.
  • The complexity of immune interactions in Mtb infection is highlighted.

Conclusions:

  • Mouse models are crucial for understanding Mtb-immune system dynamics.
  • Further dissection of immune pathways is essential for therapeutic development.
  • Contextualizing experimental data within the broader tuberculosis field is vital.