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CD23: a multi-functional receptor/lymphokine?

J Gordon, L Flores-Romo, J A Cairns

    Immunology Today
    |May 1, 1989
    PubMed
    Summary
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    CD23, also known as the low affinity IgE Fc receptor (Fc epsilon RII), plays a key role in B-cell growth regulation. This study reconciles diverse theories on CD23

    Area of Science:

    • Immunology
    • Molecular Biology
    • Cell Biology

    Background:

    • CD23 and the low affinity IgE Fc receptor (Fc epsilon RII) have been identified as the same molecule.
    • Evidence suggests CD23, also termed 'Blast-2' antigen, is crucial for B-cell growth regulation.

    Purpose of the Study:

    • To reconcile the distinct theories regarding the primary function of CD23.
    • To propose a structural model explaining the observed biological pleiotropy of CD23.

    Main Methods:

    • Review and synthesis of existing immunological research on CD23.
    • Analysis of structural and functional data related to CD23.

    Main Results:

    • Demonstration of the identity between CD23 and Fc epsilon RII.

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  • Accumulating evidence implicates CD23 in B-cell growth regulation.

    • Conclusions:

    • The study aims to bridge the gap between CD23's role as an IgE receptor and its broader function in B-cell processes.
    • A structural model is proposed to explain the multifaceted biological activities of CD23.