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Updated: Apr 23, 2026
11:22
Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
Published on: October 15, 2019
29.3K
[Intestine microbiota and allergic diseases]
Zhurnal Mikrobiologii, Epidemiologii I Immunobiologii
|October 8, 2014
Summary
Exposure to cow shed microbes like Acinetobacter lwoffii F78 may prevent allergies by activating immune responses. Early gut microbiome manipulation shows promise for preventing allergic sensitization in children.
Area of Science:
- Immunology
- Microbiology
- Allergology
Context:
- Increased incidence of immune system disorders and allergies in industrialized nations.
- Allergic diseases often co-occur with childhood inflammatory conditions.
- Growing evidence links gut microbiota to immune system development and allergy risk.
Purpose:
- To investigate the potential of microbial components from farm environments to prevent allergies.
- To explore the role of Acinetobacter lwoffii F78 and probiotic lactobacilli in modulating immune responses related to allergy.
Summary:
- Acinetobacter lwoffii F78 from cowsheds demonstrated protection against experimental allergy in mice by activating Th1-polarized dendritic cells.
- Probiotic lactobacilli may inhibit mast cell activation and the release of allergic mediators.
- The study supports the 'hygiene hypothesis,' suggesting early gut microbiome manipulation can prevent allergic sensitization.
Impact:
- Highlights microbial components from farm environments as potential allergy preventatives.
- Suggests novel therapeutic and prophylactic strategies for allergy patients based on gut microbiota modulation.
- Provides a basis for early-life interventions to prevent allergic sensitization.
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