Related Experiment Video
Updated: Apr 22, 2026
04:59
Cheek Injection Model for Simultaneous Measurement of Pain and Itch-related Behaviors
Published on: September 27, 2019
12.6K
[Transmission and modulation of itch].
Jesper Elberling1, Lars Arendt-Nielsen
1Dermato-venerologisk Afdeling, Bispebjerg Hospital, Bispebjerg Bakke 23, 2400 København NV.
Ugeskrift for Laeger
|October 9, 2014
Summary
Chronic itch significantly impacts quality of life and may involve neuronal sensitization. New, effective treatments are urgently needed for this widespread condition.
Area of Science:
- Neuroscience
- Dermatology
- Pharmacology
Context:
- Chronic itch is a debilitating symptom affecting quality of life in various disorders.
- Neuronal sensitization of peripheral and central structures can maintain or worsen chronic itch.
- Current treatments for chronic itch are often limited in efficacy and speed.
Purpose:
- To review the fundamental aspects of itch.
- To explain the neuronal transmission and modulation of itch.
- To discuss emerging treatment opportunities for chronic itch.
Summary:
- This review covers the basic science of itch, including how it is transmitted and modulated through neuronal pathways.
- It highlights the significant impact of chronic itch on patient well-being.
- The review explores potential new therapeutic strategies to address the unmet need for effective itch relief.
Impact:
- Provides a comprehensive overview of chronic itch mechanisms for researchers and clinicians.
- Identifies knowledge gaps and areas for future research in itch management.
- Highlights the urgent need for novel, targeted therapies to improve patient outcomes for chronic itch sufferers.
Related Concept Videos
01:16Sensory Functions of the Skin
8.6K
The skin is the largest organ of the human body and plays a crucial role in our sensory perception. It contains a vast network of sensory receptors that contribute to the skin's protective function by perceiving physical, biological, and environmental cues and generating relevant responses.
There are two main categories of receptors on the skin: capsulated and non-capsulated. The non-capsulated ones are mainly the pain receptors. The capsulated ones can be further categorized based on the...
There are two main categories of receptors on the skin: capsulated and non-capsulated. The non-capsulated ones are mainly the pain receptors. The capsulated ones can be further categorized based on the...
8.6K
01:43Thermosensation
29.6K
Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
29.6K
01:33Somatosensation
36.8K
The somatosensory system relays sensory information from the skin, mucous membranes, limbs, and joints. Somatosensation is more familiarly known as the sense of touch. A typical somatosensory pathway includes three types of long neurons: primary, secondary, and tertiary. Primary neurons have cell bodies located near the spinal cord in groups of neurons called dorsal root ganglia. The sensory neurons of ganglia innervate designated areas of skin called dermatomes.
36.8K
01:44Nociception
28.3K
Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.
28.3K
01:25Introduction to the Integumentary System
17.2K
The integumentary system is the organ system that comprises the skin and its associated structures. It is the largest system in the human body and plays a crucial role in protecting and maintaining homeostasis. The integumentary system serves several functions including protection, regulation, sensation, and secretion.
The skin, which is the primary organ of the integumentary system, consists of three main layers: the epidermis, dermis, and hypodermis (subcutaneous tissue). The epidermis is the...
The skin, which is the primary organ of the integumentary system, consists of three main layers: the epidermis, dermis, and hypodermis (subcutaneous tissue). The epidermis is the...
17.2K
01:28Major Somatic Sensory Pathways
3.2K
Sensory impulses related to touch, pressure, vibration, and proprioception from various body parts, such as the limbs, trunk, neck, and posterior head, travel to the cerebral cortex through the posterior column-medial lemniscus pathway. The pathway’s name derives from the two white-matter tracts that convey the impulses: the spinal cord's posterior column and the brainstem's medial lemniscus. First-order sensory neurons extend their axons into the spinal cord, forming the...
3.2K