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Updated: Apr 22, 2026

Cheek Injection Model for Simultaneous Measurement of Pain and Itch-related Behaviors
Published on: September 27, 2019
[Transmission and modulation of itch]
Jesper Elberling1, Lars Arendt-Nielsen
1Dermato-venerologisk Afdeling, Bispebjerg Hospital, Bispebjerg Bakke 23, 2400 København NV.
Abstract:
Chronic itch is an annoying and disabling symptom that severely affects patients' quality of life in several dermatological as well as non-dermatological disorders. Chronic itch may be maintained and even aggravated by sensitization of peripheral and central neuronal structures. The possibilities to effectively relieve chronic itch are often limited and the need of more specific, effective and quick-acting treatment options is huge. This review summarizes the fundamental aspects of itch, the neuronal transmission and modulation of itch, and discusses new treatment opportunities.
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