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Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography
07:11

Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography

Published on: October 28, 2020

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Right ventricular dysfunction, late gadolinium enhancement, and female gender predict poor outcome in patients with

Christina Doesch1, Désirée-Marie Dierks2, Dariusch Haghi1

  • 11st Department of Medicine, Cardiology, University Medical Centre Mannheim, Medical Faculty Mannheim, University of Heidelberg, Germany; DZHK (German Centre for Cardiovascular Research) partner site, Mannheim, Germany.

International Journal of Cardiology
|October 12, 2014
PubMed

Insights

Cardiovascular magnetic resonance imaging (CMR) parameters, including late gadolinium enhancement (LGE) and right ventricular ejection fraction (RV-EF), offer crucial prognostic insights in dilated cardiomyopathy (DCM) patients, surpassing traditional left ventricular function assessments.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Biomarkers

Background:

  • Dilated cardiomyopathy (DCM) presents a variable clinical course with substantial morbidity and mortality.
  • Current risk stratification primarily relies on left ventricular function (LVF), which has limited individual outcome prediction.
  • Novel imaging biomarkers are needed for more accurate prognostication in DCM.

Purpose of the Study:

  • To investigate the prognostic value of cardiovascular magnetic resonance imaging (CMR) parameters, specifically late gadolinium enhancement (LGE) and epicardial adipose tissue (EAT).
  • To assess the utility of these CMR findings in predicting outcomes in patients with DCM.
  • To compare the prognostic performance of CMR parameters against traditional LVF measures.

Main Methods:

  • A cohort of 140 DCM patients underwent LGE-CMR.
  • Median follow-up was 3 years, with assessment of all-cause mortality and hospitalization for congestive heart failure (CHF).
  • Multivariable analysis was employed to identify independent predictors of adverse outcomes.

Main Results:

  • Female gender and right ventricular ejection fraction (RV-EF) below 38% independently predicted all-cause mortality.
  • RV-EF below 38% was the sole independent predictor for CHF hospitalization.
  • Patients who died showed a higher prevalence of LGE and reduced EAT compared to those hospitalized for CHF.

Conclusions:

  • Female gender, RV-EF, and the presence of LGE are significant prognostic indicators in DCM.
  • CMR is a valuable tool for enhancing risk stratification in DCM patients.
  • These findings support the integration of CMR-derived parameters into clinical decision-making for DCM management.
Abstract

Keywords:
Cardiovascular magnetic resonance imagingDilated cardiomyopathyRight ventricular ejection fractionRisk stratification

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