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Updated: Apr 21, 2026

Author Spotlight: Exploring the Role of Ion Channels in Cancer: Characterization and Potential Treatment Approaches
Published on: June 16, 2023
Possible effect of variable membrane potential of a cancer cell on different carcinogenic processes
G Gogichadze1, T Gogichadze1, E Misabishvili1
1Tbilisi State Medical University, Georgia.
Abstract:
Cancer cells (unlike normal analogs) have a variable membrane potential on their surface, which depends on the intensity of metabolism of this type of cells and the environmental hydrogen index: in the case of low-pH (acid medium) they are known to have either a low negative or even positive charge, while in the case of high-pH (alkaline medium) - a relatively high negative charge. In this paper we suggest that the processes of metastasis, progression and invasion ongoing in a macro organism can be ascribed to the presence of exactly this variable electric charge in a cancer cell.
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