Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pulmonary Hypertension: Classification and Pathogenesis01:30

Pulmonary Hypertension: Classification and Pathogenesis

885
Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
885
Cardiovascular Drugs: Classification based on Therapeutic Indications01:18

Cardiovascular Drugs: Classification based on Therapeutic Indications

4.1K
Cardiovascular diseases, encompassing a range of conditions, can significantly affect the heart's operations and the overall circulatory system. These conditions impair the heart's ability to pump blood, leading to a deficit in oxygen supply to crucial organs. Anomalies in the heart's electrical system, known as arrhythmias, can cause heartbeats to accelerate or slow down. Usually, heart rates increase during physical activity and decrease while resting or sleeping. However,...
4.1K
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

1.6K
Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
1.6K
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

4.4K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
4.4K
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

1.4K
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
1.4K
Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

1.7K
Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
1.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Optimizing Care Delivery by Applying an Innovative Shared Medical Appointment Model for Determination of Cochlear Implant Candidacy.

Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·2021
Same author

Intratympanically Delivered Steroids Impact Thousands More Inner Ear Genes Than Systemic Delivery.

The Annals of otology, rhinology, and laryngology·2019
Same author

CHEER National Study of Chronic Rhinosinusitis Practice Patterns: Disease Comorbidities and Factors Associated with Surgery.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery·2017
Same author

Ménière's Disease: A CHEER Database Study of Local and Regional Patient Encounter and Procedure Patterns.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery·2016
Same author

Thyroid Disease and Surgery in CHEER: The Nation's Otolaryngology-Head and Neck Surgery Practice-Based Network.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery·2016
Same author

Tonsillectomy Bleed Rates across the CHEER Practice Research Network: Pursuing Guideline Adherence and Quality Improvement.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery·2016
Same journal

Streaming with Hearing Aids for Adolescents Who Are Hard of Hearing.

Seminars in hearing·2026
Same journal

Challenges Faced by Adolescents Who Are Deaf or Hard of Hearing: Then and Now.

Seminars in hearing·2026
Same journal

Epilogue: The Final Four.

Seminars in hearing·2026
Same journal

Implications of Legislation to Ban Cell Phones in Public Schools on the Use of Hearing Assistive Technology.

Seminars in hearing·2026
Same journal

The Role of Auditory Status and Emotion Intensity in Facial Emotion Recognition by Adolescents.

Seminars in hearing·2026
Same journal

The Differential Effects of Auditory Status on the Number and Type of Extracurricular Activities and Subsequent Social Satisfaction in Adolescents.

Seminars in hearing·2026
See all related articles

Related Experiment Video

Updated: Apr 21, 2026

Cryosectioning and Immunostaining Mouse Inner Ear Tissue: From Embryonic to Adult Stages
09:09

Cryosectioning and Immunostaining Mouse Inner Ear Tissue: From Embryonic to Adult Stages

Published on: April 11, 2025

2.2K

Vascular Pathophysiology in Hearing Disorders.

Dennis R Trune1, Anh Nguyen-Huynh1

  • 1Oregon Hearing Research Center, Department of Otolaryngology/Head & Neck Surgery Oregon Health & Science University, Portland, OR 97239 USA.

Seminars in Hearing
|October 28, 2014
PubMed
Summary
This summary is machine-generated.

Inner ear blood vessels maintain function but can also cause hearing loss by facilitating inflammation. This review explores vascular biology and pathophysiology in hearing dysfunction.

Keywords:
blood vesselsblood-labyrinth barrierglycocalyxhearing lossimmunopathology

More Related Videos

Isolation and Culture of Primary Marginal Cells of the Stria Vascularis from Neonatal Mice
07:58

Isolation and Culture of Primary Marginal Cells of the Stria Vascularis from Neonatal Mice

Published on: March 20, 2026

100
Measurement of Strial Blood Flow in Mouse Cochlea Utilizing an Open Vessel-Window and Intravital Fluorescence Microscopy
09:52

Measurement of Strial Blood Flow in Mouse Cochlea Utilizing an Open Vessel-Window and Intravital Fluorescence Microscopy

Published on: September 21, 2021

2.1K

Related Experiment Videos

Last Updated: Apr 21, 2026

Cryosectioning and Immunostaining Mouse Inner Ear Tissue: From Embryonic to Adult Stages
09:09

Cryosectioning and Immunostaining Mouse Inner Ear Tissue: From Embryonic to Adult Stages

Published on: April 11, 2025

2.2K
Isolation and Culture of Primary Marginal Cells of the Stria Vascularis from Neonatal Mice
07:58

Isolation and Culture of Primary Marginal Cells of the Stria Vascularis from Neonatal Mice

Published on: March 20, 2026

100
Measurement of Strial Blood Flow in Mouse Cochlea Utilizing an Open Vessel-Window and Intravital Fluorescence Microscopy
09:52

Measurement of Strial Blood Flow in Mouse Cochlea Utilizing an Open Vessel-Window and Intravital Fluorescence Microscopy

Published on: September 21, 2021

2.1K

Area of Science:

  • Inner ear biology
  • Vascular pathophysiology
  • Oto-immunology

Background:

  • Inner ear vasculature maintains the blood-labyrinth barrier, hormone transport, and nutrient supply.
  • These vessels also transmit systemic inflammatory factors, contributing to inner ear dysfunction.
  • Despite critical roles, inner ear vascular homeostasis and disease mechanisms remain poorly understood.

Purpose of the Study:

  • To review current concepts in inner ear vascular biology.
  • To discuss natural vascular responses to circulating inflammatory factors.
  • To elucidate how vascular pathophysiology contributes to hearing loss.

Main Methods:

  • Literature review of vascular biology and pathophysiology.
  • Analysis of inflammatory factor interactions with inner ear vasculature.
  • Synthesis of mechanisms linking vascular dysfunction to hearing impairment.

Main Results:

  • Inner ear blood vessels are vital for homeostasis but implicated in disease.
  • Vascular responses to inflammation can compromise inner ear function.
  • Pathophysiological changes in vasculature are a key factor in hearing loss.

Conclusions:

  • Understanding inner ear vascular biology is crucial for addressing hearing loss.
  • Targeting vascular mechanisms may offer new therapeutic strategies.
  • Further research is needed on vascular homeostasis and disease in the inner ear.