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Published on: October 13, 2023
[Every fifth case of multiple sclerosis is familial]
Stefanie Binzer1, Michael Binzer, Kirsten Ohm Kyvik
1Neurologisk Ambulatorium, Forskningsenheden, Sygehus Sønderjylland, Sydvang 1, 6400 Sønderborg. sbinzer@health.sdu.dk.
Abstract:
Up to 20% of all multiple sclerosis (MS) cases are familial. The concordance rates for monozygotic and dizygotic twins are 25-30% and 3-5% respectively. Certain isolated regions have a higher prevalence of MS. An estimated 30% of the disease heritability is accounted for, mostly by common risk alleles. Interpretation of risk alleles, gene-gene and gene-environment interactions is challenging, but all are believed to be important factors in the development of MS. Isolates and MS families are warranted for further research concerning these issues.
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