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Updated: Apr 21, 2026

In Vivo Augmentation of Gut-Homing Regulatory T Cell Induction
Published on: January 22, 2020
[Optimized thiopurine treatment in chronic inflammatory bowel disease]
Marianne Kiszka-Kanowitz1, Klaus Theede, Anette Mertz Nielsen
1Gastroenheden, Medicinsk -sektion, Hvidovre Hospital, Kettegårds Allé 30, 2650 Hvidovre. marianne.kiszka-kanowitz@regionh.dk.
Abstract:
Thiopurines are effective in maintaining remission in chronic inflammatory bowel diseases, but incomplete response or side effects are common during standard-dose treatment. In this article thiopurine metabolism and pharmacogenetic aspects are summarized showing their benefits in improving therapy in chronic inflammatory bowel disease. An increasing body of evidence suggests that a large part of the observed non-pancreatic side effects and poor responses can be solved by tailoring thiopurine therapy using measurement of thiopurine methyltransferase and metabolites and by using a combination therapy with low-dose thiopurines and allopurinol.
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