Related Experiment Video
Updated: Jul 29, 2026
Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity
Published on: March 16, 2018
Effect of gentamicin on the auditory analyzer in sexually immature animals
I N D'yakonova1, Yu S Ishanova, I V Rakhmanova
1Department of Physiology, Medicobiological Faculty, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia.
Abstract:
Auditory function of immature rabbits was evaluated using two electrophysiological methods, brainstem auditory evoked response (BAER) and distortion product otoacoustic emission (DPOAE), in chronic experiments following administration of therapeutic doses of gentamicin. Impairment of auditory function manifested in increased thresholds and decreased amplitude of the 1st BAER peak was established. DPOAE parameters were not significantly changed. It was suggested that gentamicin decreased activity of spiral ganglion neurocytes in animals with immature auditory analyzer.
