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[Evaluation of postvaccinal pertussis immunity by using immunoenzyme analysis]
Zhurnal Mikrobiologii, Epidemiologii I Immunobiologii
|January 1, 1989
Summary
This study assessed DPT vaccine effectiveness in children, finding it induced significant immunoglobulin levels but immunity waned after two years, preventing disease but not infection.
Area of Science:
- Immunology
- Vaccinology
- Pediatric Infectious Diseases
Background:
- The effectiveness of adsorbed Diphtheria-Pertussis-Tetanus (DPT) vaccine was evaluated.
- Assessing immunoglobulin response and duration of immunity to pertussis antigens is crucial.
Purpose of the Study:
- To evaluate the effectiveness of USSR-manufactured adsorbed DPT vaccine.
- To assess its capacity to induce immunoglobulin classes and the duration of immune response.
Main Methods:
- Modified Enzyme Immunoassay (EIA) was used for evaluation.
- Study involved 273 children immunized with adsorbed DPT vaccine.
Main Results:
- 87.2% of immunized children developed IgG antibodies, 14.1% IgA, and 3.2% IgM.
- Full DPT immunization course led to significantly higher immunity levels compared to primary course or unvaccinated children.
- Antipertussis immunity decreased two years post-immunization and in children over 5-6 years old.
Conclusions:
- Adsorbed DPT vaccine prevented pertussis disease but not infection.
- Post-infection immunity was found to be stronger than post-vaccinal immunity.