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Related Concept Videos

Colonisation of Pathogens01:25

Colonisation of Pathogens

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Pathogen colonization of host tissues is a critical step in the development of infectious diseases. Various pathogenic microorganisms, including bacteria, fungi, viruses, and protozoa, have evolved complex strategies to attach to, invade, and persist within host environments. These mechanisms enable pathogens to establish infections, evade immune responses, and resist antimicrobial treatments.Attachment to Host CellsIn bacteria, colonization typically begins with adherence to host epithelial...
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Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
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A Comparative Approach to Characterize the Landscape of Host-Pathogen Protein-Protein Interactions
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The Pathogen-Host Interactions database (PHI-base): additions and future developments.

Martin Urban1, Rashmi Pant2, Arathi Raghunath2

  • 1Department of Plant Biology and Crop Science, Rothamsted Research, Harpenden, Herts, AL5 2JQ, UK martin.urban@rothamsted.ac.uk.

Nucleic Acids Research
|November 22, 2014
PubMed
Summary
This summary is machine-generated.

The Pathogen-Host Interactions database (PHI-base) catalogs experimentally verified genes and phenotypes for bacterial, fungal, and protist pathogens. This resource aids in understanding host-pathogen interactions to combat diseases affecting crops and health.

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Area of Science:

  • Microbiology
  • Genomics
  • Bioinformatics

Background:

  • Pathogens pose significant threats to agriculture, human health, and ecosystems.
  • Understanding pathogen-host interactions is crucial for developing effective disease control strategies.
  • Comparative knowledge across species is needed to combat diverse infections.

Purpose of the Study:

  • To present PHI-base 3.6, a curated database of experimentally verified pathogenicity, virulence, and effector genes.
  • To associate mutant phenotypes with gene information for various pathogens and hosts.
  • To facilitate comparative analysis of pathogen-host interactions across different species.

Main Methods:

  • Manual curation of peer-reviewed literature to gather gene and phenotypic data.
  • Cataloging information on bacterial, fungal, and protist pathogens and their hosts.
  • Utilizing a controlled vocabulary for phenotype classification and data analysis.
  • Mapping PHI-base phenotypes to reference genomes in Ensembl Genomes.

Main Results:

  • PHI-base 3.6 contains data on 2875 genes, 4102 interactions, 110 host species, and 160 pathogenic species.
  • Information covers 181 diseases from 1243 references.
  • Virulence genes and hotspots are visualized in genome browsers.

Conclusions:

  • PHI-base provides a valuable resource for studying pathogen-host interactions.
  • The database supports comparative analysis and understanding of disease mechanisms.
  • Future development includes community curation and host target inclusion.